姓名：房新强
性别：男
学位/职称：博士/教授
研究方向：不对称催化、金属有机化学
邮箱：xqfang@ahnu.edu.cn
个人简介：房新强，安徽师范大学教授。2002年本科毕业于鲁东大学，2005年硕士毕业于中国科学技术大学，2009年在上海有机化学研究所获得博士学位，随后分别在新加坡南洋理工大学和美国德州农工大学、康奈尔大学从事博士后研究，2013年加入中国科学院福建物质结构研究所，任课题组长、博士生导师，2026年入职安徽师范大学，被聘为讲席教授。主要从事不对称催化、金属有机化学方面的研究。目前以第一作者和通讯作者在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Nat. Commun.、ACS Catal. 等国内外著名期刊发表学术论文80余篇，获得海外高层次人才计划、中科院百人计划、安徽省百人计划、国家自然科学基金面上项目、青年科学基金(C类)等项目的支持。
主持承担科研项目：
1.国家自然科学基金委员会，面上项目，22571300，基于炔-烯丙基取代反应的协同催化和接力催化研究， 2026-01-01至2029-12-31，在研，主持
2.国家自然科学基金委员会，面上项目, 22071242, 基于亲核性酰基烯醇负离子中间体的不对称催化研究2021-01-01至2024-12-31, 结题，主持
3.国家自然科学基金面上项目，21871260，基团添加法导向的动力学拆分制备手性叔醇和α-取代酮，2019-01-01至2022-12-30，结题，主持
4.国家自然科学基金青年基金，21502192，基于亲核-亲电双重反应活性底物设计和氧化型氮杂环卡宾催化的多取代手性环状化合物的合成研究，2015-01-01至2017-12-30，结题，主持
代表性论文：
1. Shouang Lan,§ Yingkun Luo,§ Chunyun Jiang, Chao Xu, Lili Zhao, Xiang Lei, Jieyang Dong, Jinggong Liu, Shuang Yang, Qi Zhang*, Xinqiang Fang*, Ruthenium-Catalyzed Diversified Kinetic Resolutions of Diaryl-Substituted Cyclobutenones via Asymmetric Transfer Hydrogenation. Angew. Chem. Int. Ed. 2025, 64, e202512543.
2. Shouang Lan,§ Qinqin Cui,§ Defu Luo, Siyu Shi, Chengyang He, Shengyu Huang, Chao Xu, Lili Zhao, Jinggong Liu*, Cheng-Zhi Gu*, Shuang Yang, Xinqiang Fang*, Copper-Catalyzed Asymmetric Nucleophilic Opening of 1,1,2,2-Tetrasubstituted Donor-Acceptor Cyclopropanes for the Synthesis of α-Tertiary Amines. J. Am. Chem. Soc. 2025, 147, 1172−1185.
3. Zhifei Zhao,§ Wennan Dong,§ Jinggong Liu, Shuang Yang, Andrej Emanuel Cotman, Qi Zhang*, Xinqiang Fang*, Catalytic Asymmetric Transfer Hydrogenation of β,γ-Unsaturated α-Diketones. J. Am. Chem. Soc. 2024, 146, 33543−33560.
4. Wenjun Liu, Caiyi Ren, Liyuan Zhou, Haotian Luo, Xiangjian Meng, Peng Luo, Yingkun Luo, Wennan Dong, Shouang Lan, Jinggong Liu, Shuang Yang, Qi Zhang*, Xinqiang Fang*, Regio- and Stereoselective Transfer Hydrogenation of Aryloxy Group-Substituted Unsymmetrical 1,2-Diketones: Synthetic Applications and Mechanistic Studies. J. Am. Chem. Soc. 2024, 146, 20092–20106.
5. Catalytic Asymmetric Transfer Hydrogenation of Acylboronates: BMIDA as the Privileged Directing Group. Xiangjian Meng,§ Shouang Lan,§ Ting Chen, Haotian Luo, Lixuan Zhu, Nanchu Chen, Jinggong Liu, Shuang Yang, Andrej Emanuel Cotman, Qi Zhang*, Xinqiang Fang*, J. Am. Chem. Soc. 2024, 146, 20357–20369.
6. Asymmetric Transfer Hydrogenation of Cyclobutenediones. Shouang Lan,§ Huangjiang Huang,§ Wenjun Liu, Chao Xu, Xiang Lei, Wennan Dong, Jinggong Liu, Shuang Yang, Andrej Emanuel Cotman, Qi Zhang*, and Xinqiang Fang*, J. Am. Chem. Soc. 2024, 146, 4942−4957.
7. Copper-catalyzed Asymmetric Yne-allylic Substitution Using Electron-rich Arenes. Defu Luo,§ Shengtong Niu,§ Fan Gong, Chao Xu, Shouang Lan, Jinggong Liu*, Shuang Yang, Xinqiang Fang*, ACS Catal. 2024, 14, 2746–2757.
8. Ruthenium-Catalyzed Formal Asymmetric Reductive Isomerization of α-Hydroxyenones. Wennan Dong, Caiyi Ren, Lixuan Zhu, Peng Luo, Zhifei Zhao, Shouang Lan, Jinggong Liu, Shuang Yang, Qi Zhang*, Xinqiang Fang*, ACS Catal. 2024, 14, 18753−18764.
9 Copper-catalyzed Umpolung Reactivity of Propargylic Carbonates in the Presence of Diboronates: One Stone Four Birds. Wennan Dong, Zhifei Zhao, Chengzhi Gu*, Jinggong Liu, Shuang Yang, Xinqiang Fang*, J. Am. Chem. Soc. 2023, 145, 27539−27554.
10. Copper-Catalyzed Rearrangement of Cyclic Ethynylethylene Carbonates: Synthetic Applications and Mechanistic Studies. Chao Xu,§ Hao Zhang,§ Shouang Lan, Jinggong Liu, Shuang Yang, Qi Zhang*, and Xinqiang Fang*, Angew. Chem. Int. Ed. 2023, 62, e202219064.
11. Dynamic Kinetic Resolution of β-Substituted α-Diketones via Asymmetric Transfer Hydrogenation. Ting Chen,§ Wenjun Liu,§ Wei Gu, Shengtong Niu, Shouang Lan, Zhifei Zhao, Fan Gong, Jinggong Liu, Shuang Yang, Andrej Emanuel Cotman, Jinshuai Song*, Xinqiang Fang,* J. Am. Chem. Soc. 2023, 145, 585−599.
12. Asymmetric Semipinacol Rearrangement Enabled by Copper-Catalyzed Propargylic Alkylation. Fan Gong,§ Xiangjian Meng,§ Shouang Lan, Jinggong Liu, Shuang Yang, Xinqiang Fang*, ACS Catal. 2022, 12, 12036−12044.
13. Copper-Catalyzed Yne-Allylic Substitutions Using Stabilized Nucleophiles. Shengtong Niu, Yingkun Luo, Chao Xu, Jinggong Liu, Shuang Yang, Xinqiang Fang*, ACS Catal. 2022, 12, 6840–6850.
14. Access to Enantioenriched Compounds Bearing Challenging Tetrasubstituted Stereocenters via Kinetic Resolution of Auxiliary Adjacent Alcohols. Shengtong Niu,† Hao Zhang,† Weici Xu*, Prasanta Ray Bagdi, Guoxiang Zhang, Jinggong Liu, Shuang Yang, and Xinqiang Fang*, Nat. Commun. 2021, 12: 3735.
15. Organocatalyzed Kinetic Resolution of a-Functionalized Ketones: the Malonate Unit Leads the Way. Jian Liu,# Laxmaiah Vasamsetty,# Muhammad Anwar,# Shuang Yang*, Weici Xu, Jinggong Liu, Sakkani Nagaraju, and Xinqiang Fang*, ACS Catal. 2020, 10, 2882−2893.
16. A Genetically Encoded Allysine for the Synthesis of Proteins with Site-Specific Lysine Dimethylation. Zhipeng A. Wang, Yu Zeng, Yadagiri Kurra, Xin Wang, Jeffery M. Tharp, Erol C. Vatansever, Willie W. Hsu, Susie Dai, Xinqiang Fang*, Wenshe R. Liu*, Angew. Chem., Int. Ed. 2017, 56, 212−216.
17. Dynamic Kinetic Resolution Enabled by Intramolecular Benzoin Reaction: Synthetic Applications and Mechanistic Insights. Guoxiang Zhang, Shuang Yang, Xiaoyan Zhang, Qiqiao Lin, Deb K. Das, Jian Liu, Xinqiang Fang*, J. Am. Chem. Soc. 2016, 138, 7932−7938.
